• Æóҵչʾ

    Ê×Ò³
    ¡¡¡ª¡¡Æóҵչʾ
    ¡¡¡ª¡¡ÆóÒµÐÂÎÅ

    ¿áÓιÙÍø-¿ÆÑ§¼Ò·¢ÏÖ°¢¶û´Äº£Ä¬²¡µÄÐÂÐÍÉúÎï±êÖ¾Îï

    ¿ÆÑ§¼Ò·¢Ã÷°¢¶û´Äº£Ä¬²¡µÄÐÂÐÍÉúÎï±ê¼ÇÎï

    ÈÕÆÚ£º2023-02-06 À´Àú£º±¾Õ¾ ¹©¸å£º¹ú¼Ê»¥ÖúÓë»ùµØÆ½Ì¨´¦ ×÷ÕߣºÖÎÀíÔ± ÖÖ±ð£ºÒëÎÄ

    ³£È¾É«ÌåÏÔÐÔÒÅ´«ÐÔ°¢¶û´Äº£Ä¬²¡£¨ADAD£©ÊÇÓɵí·ÛÑùǰÌåÂѰס¢ÔçÀÏËØ1»òÕßÔçÀÏËØ2»ùÒòµÄÖ²¡Í»±äÒýÆðµÄ¡£ADADµÄ²¡ÀíÐÄÀíת±äÓÚ³ÊÏÖÁÙ´²Ö¢×´µÄ¼¸Ê®Äêǰ¾ÍÒѾ­¾­×îÏÈÁË£¬³õÆÚÕï¶ÏÓÐÖúÔÚ´ó·òÊ©ÓÃÒ©Îﻺ½â»¼Õß²¡Çé¡£½üÆÚ£¬À´×Ô¿¨ÂÞÁÖ˹¿¨Ò½Ñ§Ôº¡¢±ùµº¼°Ó¢¹úµÄ¿ÆÑ§¼Ò·¢Ã÷£¬Ò»ÖÖÃûΪ½ºÖÊÏËάËáÐÔÂѰף¨GFAP£©µÄÂѰ×ÖʶàÊǸü²²¡³õÆÚ½×¶ÎµÄÉúÎï±ê¼ÇÎï¡£Ñо¿½á¹û·¢±íÓÚ¡¶Brain¡·ÆÚ¿¯£¬±êÌâΪ¡°Plasma biomarker profiles in autosomaldominant Alzheimer¡¯s disease¡±¡£ Ñо¿Ö°Ô±ÆðÊ×½«33ÃûÍ»±äЯ´øÕߣ¨MC£©¼°42Ãû·ÇЯ´øÕߣ¨NC£©µÄ164·ÝѪ½¬Ñù±¾ÄÉÈëÃþË÷ÐÔ×ÝÏò²û·¢£¬ËùÓÐÑù±¾¾ùÀ´×ÔÈðµäµÄÒ»ÏîADADǰհÐÔÐÐÁв½¶Ó£¬¸ÃÐÐÁв½¶ÓÊý¾ÝÍøÂçÔÚ1994ÄêÖÁ2018ÄêʱÆÚ¡£Æä´Î£¬Ñо¿Ö°Ô±ÀûÓõ¥·Ý×ÓÃâÒß¿áÓιÙÍø-ÕóÁм¼ÄÜÕÉÁ¿ÁËѪ½¬Á×Ëữtau£¨P-tau181£©¡¢×Ütau£¨T-tau£©¡¢Éñ¾­Ë¿ÇáÁ´£¨NfL£©¼°GFAPµÄŨ¶È¡£Ñо¿³É¹ûÏÔʾ£¬ÓëNC±ÈÄ⣬MCµÄѪ½¬ÂѰ×P-tau18Ò»¡¢NfL¼°GFAPµÄŨ¶È¸ü¸ß£»GFAPµÄŨ¶ÈÓÚADADÖ¢×´³ÊÏÖǰ10Äê°Ú²¼×îÏÈÔö³¤£¬P-tau181¼°NfLŨ¶ÈÓÚ¿¿½üÖ¢×´³ÊÏÖʱÔö³¤¡£´ËÍ⣬Ñо¿Ö°Ô±»¹Óвû·¢ÁËÕâЩÐÂÐÍѪ½¬ÉúÎï±ê¼ÇÎïŨ¶ÈÓëÄÔ¼¹ÒºÖÐÉúÎï±ê¼ÇÎïP-tau181£¬T-tau¼°¸÷Àà¦Â-µí·ÛÑùÂѰ׵ÄÏà¸ÉÐÔ¡£Ñо¿³É¹û×¢½â£¬Ñª½¬P-tau181³Ì¶ÈÓëÄÔ¼¹ÒºÖÐP-tau181ÓëT-tauµÄ³Ì¶ÈÏà¸ÉÁª¡£ ×ÜÖ®£¬¸ÃÑо¿·¢Ã÷µÄѪ½¬GFAPÓÐÍû³ÉΪADAD³õÆÚÕï¶ÏµÄÉúÎï±ê¼ÇÎÕâ¶ÔÓÚÔÚADADµÄ³õÆÚ·¢Ã÷¼°ºÍʱ¸ÉÉæ¸ÉÓëÒâÒåÅÓ´ó¡£ ÂÛÎÄÁ´½Ó£ºhttps://academic.oup.com/brain/advance-article/doi/10.1093/brain/awac399/6979878?login=false ×¢£º´ËÑо¿½á¹ûÕª×Ô¡¶Brain¡·ÆÚ¿¯Ô­ÎÄÕ£¬ÎÄÕÂÄÚÈݲ»´ú±í±¾ÍøÕ¾²»Ñŵ㼰̬¶È£¬½ö¹©²Î¿¼¡£-¿áÓιÙÍø-

    »áÔ±µÇ¼

    ·µ»Ø¶¥²¿

    ×¢²á
    ¨w

    ÐÕÃû*

    ¹«Ë¾Ãû³Æ*

    ÓÊÏä*

    µç»°ºÅÂë*

    ÑéÖ¤Âë* »ñÈ¡ÑéÖ¤Âë

    ÄúÏë×ÉѯµÄÒµÎñ*

    怬
    ¨w

    µç»°ºÅÂë*

    ÑéÖ¤Âë* »ñÈ¡ÑéÖ¤Âë

    ×¢²áÕ˺Å

    ÍêÉÆÐÅÏ¢
    ¨w

    ¹«Ë¾Ãû³Æ*

    ÐÕÃû*

    ÓÊÏä*

    ÄúÏë×ÉѯµÄÒµÎñ*

    ¨w
    ×¢²áÐëÖª

    ×¢²áÕ˺Å

    ²¿·Ö±¾Æ½Ì¨·þÎñ½öÏò×¢²áÓû§Ìṩ£¬Èç¹ûÄúʹÓñ¾Æ½Ì¨ÌṩµÄÍøÂç´æ´¢¿Õ¼ä½øÐÐÊÓÌý¡¢ÎÄ×ÖµÈÄÚÈݵÄÉÏ´«¼°´«²¥µÈ£¬ÇëÏȸù¾Ý±¾Ð­Òé¼°ÆäËû±¾Æ½Ì¨¹æÔòÌáʾµÄ¹æÔò¡¢Á÷³Ì×¢²á³ÉΪע²áÓû§£¬²¢È·±£×¢²áÐÅÏ¢µÄÕæÊµÐÔ¡¢ÕýÈ·ÐÔ¼°ÍêÕûÐÔ£¬Èç¹ûÉÏÊö×¢²áÐÅÏ¢·¢Éú±ä»¯£¬ÄúÓ¦¼°Ê±¸ü¸Ä¡£

    ÄúÓ¦¶Ô×¢²á»ñµÃµÄ±¾Æ½Ì¨Õ˺ţ¨ÒÔϼò³Æ¡°Õ˺𱣩ÏîϵÄÒ»ÇÐÐÐΪ³Ðµ£È«²¿ÔðÈΣ¬²»µÃÇÖ·¸°üÀ¨µ«²»ÏÞÓÚ±¾Æ½Ì¨ÔÚÄÚµÄÈκÎÖ÷ÌåµÄºÏ·¨È¨Òæ¡£

    ÄúÀí½â²¢Í¬Ò⣬Äú½öÏíÓÐÕ˺ż°Õ˺ÅÏîÏÂÓɱ¾Æ½Ì¨ÌṩµÄÐéÄâ²úÆ·¼°·þÎñµÄʹÓÃȨ£¬Õ˺ż°¸ÃµÈÐéÄâ²úÆ·¼°·þÎñµÄËùÓÐȨ¹é±¾Æ½Ì¨ËùÓУ¨·¨ÂÉ·¨¹æÁíÓй涨µÄ³ýÍ⣩¡£Î´¾­±¾Æ½Ì¨ÊéÃæÍ¬Ò⣬Äú²»µÃÒÔÈκÎÐÎʽ´¦ÖÃÕ˺ŵÄʹÓÃȨ£¨°üÀ¨µ«²»ÏÞÓÚÔùÓë¡¢³ö½è¡¢×ªÈá¢ÏúÊÛ¡¢µÖѺ¡¢¼Ì³Ð¡¢Ðí¿ÉËûÈËʹÓã©¡£Èç¹û±¾Æ½Ì¨·¢ÏÖ»òÕßÓкÏÀíÀíÓÉÈÏΪʹÓÃÕß²¢·ÇÕ˺ųõʼע²áÈË£¬±¾Æ½Ì¨ÓÐȨÔÚ²»Í¨ÖªÄúµÄÇé¿öÏ£¬ÔÝÍ£»òÖÕÖ¹Ïò¸Ã×¢²áÕ˺ÅÌṩ·þÎñ£¬²¢×¢Ïú¸ÃÕ˺Å¡£

    ÄúÓ¦Í×ÉÆ±£¹ÜÕ˺ÅÐÅÏ¢¡¢Õ˺ÅÃÜÂëÒÔ¼°ÆäËûÓëÕ˺ÅÏà¹ØµÄÐÅÏ¢¡¢×ÊÁÏ¡£ÈçÒòÄúµÄÔ­Òò£¬Ôì³ÉÕ˺ÅÐÅÏ¢¡¢×ÊÁÏ¡¢Êý¾ÝµÄ±ä¶¯¡¢Ãðʧ»ò²Æ²úËðʧµÈ£¬ÄúÓ¦Á¢¼´Í¨Öª±¾Æ½Ì¨²¢×ÔÐге£Ïà¹Ø·¨Âɺó¹û¡£



    ±¾Æ½Ì¨ÉϵÄÄÚÈÝ

    ±¾Æ½Ì¨ÉϵÄÄÚÈÝÊÇÖ¸¾­Óɱ¾Æ½Ì¨ÌṩµÄ·þÎñ£¬ÒÔÉÏ´«¡¢ÕÅÌù»òÈÎºÎÆäËû·½Ê½´«ËÍ»ò´«²¥µÄÈκÎ×ÊѶ¡¢×ÊÁÏ¡¢ÎÄ×Ö¡¢Èí¼þ¡¢ÒôÀÖ¡¢ÒôƵ¡¢ÕÕÆ¬¡¢Í¼ÐΡ¢ÊÓÆµ¡¢ÐÅÏ¢¡¢Á´½Ó»òÆäËû×ÊÁÏ£¬ÎÞÂÛϵ¹«¿ª»¹ÊÇ˽Ï´«ËÍ£¨ÒÔϼò³Æ¡°ÄÚÈÝ¡±£©£¬ÄÚÈÝÌṩÕß¡¢ÉÏ´«ÕßÓ¦¶ÔÆäÌṩ¡¢ÉÏ´«µÄÄÚÈݳе£È«²¿ÔðÈΣ¬Èç¹û¸ø±¾Æ½Ì¨Ôì³ÉËðʧµÄ£¬»¹Ó¦Ïò±¾Æ½Ì¨³Ðµ£Åâ³¥ÔðÈΡ£¶ÔÓÚµÚÈý·½ÒòÓû§ÉÏ´«µÄÄÚÈÝÏò±¾Æ½Ì¨Ö÷ÕÅȨÀûµÄ£¬±¾Æ½Ì¨ÓÐȨÔÚ²»ÊÂÏÈ֪ͨÄÚÈÝÌṩÕß¡¢ÉÏ´«ÕßµÄÇé¿öÏÂÖ±½Ó²Éȡɾ³ý¡¢ÆÁ±Î¡¢¶Ï¿ªÁ´½ÓµÈ±ØÒª´ëÊ©¡£

    ÄúÔÚ±¾Æ½Ì¨ÉÏ´«»ò·¢²¼µÄÄÚÈÝ£¬Äú±£Ö¤¶ÔÆäÏíÓкϷ¨µÄÖø×÷Ȩ»òÏàÓ¦ÊÚȨ£¬±¾Æ½Ì¨ÓÐȨչʾ¡¢É¢²¼¼°ÍƹãǰÊöÄÚÈÝ¡£

    ΪÌá¸ßÄúÄÚÈÝÆØ¹âÁ¿¼°·¢²¼Ð§ÂÊ£¬±¾Æ½Ì¨½«¶îÍâΪÄúÌṩȫÇò·¶Î§ÄÚµÄչʾºÍÍÆ¹ã·þÎñ£¬ÄúͬÒâÄúÔÚ±¾Æ½Ì¨µÄÕ˺ÅËù·¢²¼µÄÈ«²¿ÄÚÈݾùÊÚȨ±¾Æ½Ì¨ÒÔÄúµÄÕ˺Åͬ²½ÖÁ±¾Æ½Ì¨ÔËÓªµÄÈ«²¿²úÆ·£¬°üÀ¨µ«²»ÏÞÓÚPC¡¢Æ½°å¡¢ÊÖ»ú¡¢µçÊÓ¡¢»ú¶¥ºÐ¡¢¿É´©´÷É豸µÈÈ«²¿¿Í»§¶ËÈí¼þºÍ/»òÍøÕ¾¡£Í¬Ê±£¬ÄúÔÊÐí±¾Æ½Ì¨ÔÚͬ²½²¢Õ¹Ê¾ÄÚÈÝʱ¿É×ÔÐлòίÍеÚÈý·½½øÐбØÒªµÄ´¦Àí£¨°üÀ¨µ«²»ÏÞÓÚ·­Òë¡¢»ã±à¡¢¸Ä±àµÈ£©¡£ÄúÔÚ´ËÈ·Èϲ¢Í¬Ò⣬±¾Æ½Ì¨ÓÐȨ×ÔÐлòίÍеÚÈý·½ÔÚÓëÉÏÊöÄÚÈÝ¡¢±¾Æ½Ì¨²úÆ·¼°Ïà¹Ø·þÎñ¡¢±¾Æ½Ì¨ºÍ/»ò±¾Æ½Ì¨Æ·ÅÆÓйصÄÈκÎÐû´«¡¢ÍƹãºÍ/»òÑо¿ÖÐÒÔÊʵ±µÄ·½Ê½¿ª·¢ºÍʹÓÃÉÏÊöÄÚÈÝ£¨È«²¿»ò²¿·Ö£©¡£